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November 10, 2024
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December 26, 2024
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Abstract

Background: Handgrip strength (HGS) is an indicator of overall muscle health and is affected by impaired blood glucose levels. This review discusses the relationship between HGS and blood glucose levels and provides solutions to the known problems of HGS and blood glucose regulation.


Methods: This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. The articles were sourced from Google Scholar and PubMed. A total of 418 studies were screened, of which 19 articles were included in this study. The Newcastle–Ottawa Scale was used to assess the risk of bias.


Results: A relationship was observed between low HGS and high blood glucose levels. The suggested mechanisms involve insulin resistance, Caspase-3 activation, and the mitochondrial impact. Sarcopenia emerged as an independent risk factor for impaired glucose control. Interventions including insulin administration and exercise have been proposed to preserve muscle mass.


Conclusion: Resistance training and HGS exercises can be added to the rehabilitation practices for managing diabetes mellitus. HGS measurements are vital for predicting muscle mass loss in clinical practice.

Keywords

Handgrip Strength Blood Glucose Young Adults Elderly Systematic Review

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Copyright (c) 2024 Lekan Sheriff Ojulari, Swabirah Eniamire Sulaiman, Olayide Sulaiman Agodirin, Mohammed Amali

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Author Biographies

Lekan Sheriff Ojulari, University of Ilorin, Nigeria

Dr. Lekan Sheriff Ojulari is a Reader at the University of Ilorin in Nigeria. He holds an MBBS, an MSc, and a PhD, demonstrating extensive expertise in medical and physiological sciences. His primary research interests are in diabetes mellitus and endocrinology, focusing on the mechanisms, treatments, and interventions for metabolic disorders.

Swabirah Eniamire Sulaiman, University of Ilorin, Nigeria

Miss Swabirah Sulaiman Enimire is a Clinical Physiologist at Nisa Premier Hospital Abuja, Nigeria. She holds a B.Sc in Human Physiology from the University of Ilorin, Nigeria. 

Olayide Sulaiman Agodirin, University of Ilorin, Nigeria

Olayide Sulaiman Agodirin is a Professor of General Surgery at the University of Ilorin, Nigeria. He holds an MBBS, an MSc in Clinical Research, an MD, and fellowships from the West African College of Surgeons and the National Postgraduate Medical College. A certified data analyst and machine learning professional, his research primarily focuses on breast cancer, emphasizing primordial prevention and early treatment.

Mohammed Amali, University of Chester, England

Mohammed Otofu Amali, PhD, is a Senior Lecturer and the BSc Pharmacology and Biochemistry Programme lead at the Faculty of Health, Medicine and Society, University of Chester Medical School. His research interests include drug allergies, but he has recently focused more on developing drugs from natural products to discover novel therapeutic molecules that can enhance current patient management strategies. 

How to Cite
Ojulari, L. S., Sulaiman, S. E., Agodirin, O. S., & Amali, M. (2024). Systematic Review of the Relationship Between Handgrip Strength and Blood Glucose Levels in Young Adults and the Elderly. Pan-African Journal of Health and Environmental Science, 3(2), 132–146. https://doi.org/10.56893/ajhes2024v03i02.08
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